Five- to six-month-old male Thy1-hAPPLond/Swe+ mice and their wild-type littermates were used in this study. Transgenic lines were maintained by crossing heterozygous Thy1-hAPPLond/Swe+ mice with C57BL/6J breeders. Littermate cage-mates were used as control mice. Five cohorts of mice with an n between nine and 19 were used. The total number of mice used was 68 controls and 65 mutants. The genotype of all animals was determined by PCR before experiments. All transgenic mice were heterozygous with respect to the hAPPLond/Swe gene. Twelve-week-old male C57BL/6J mice (from Jackson Laboratory, Bar Harbor, ME) were used for the validation of the delayed-matching-to-place (DMP) dry maze task. All animals were housed in a 12-h dark/light cycle, temperature- and humidity-controlled environment with unlimited access to water and food. The same group of animals was tested in the activity chamber, open field, and fear conditioning (FC). Different groups of mice were used for the social interaction tests, Morris water maze (MWM), DMP water maze, DMP dry maze, and hot plate test. Experimenters were blind to the genotype of the mice throughout testing. All tests were conducted in the light cycle. In all experiments, animals were habituated to the testing room 2 h before the tests and were handled by the experimenter for five days before all the behavioral tests. All experiments were in accordance with protocols approved by the Institutional Animal Care and Use Committee of Stanford University and were performed based on the National Institutes of Health Guide for the Care and Use of Laboratory Animals. All actions were considered for reducing discomfort of animals during all experiments.