In vivo studies were performed in the OVCAR5 xenograft model using female athymic nude mice (nu/nu, 4–6 weeks old; Jackson Laboratory, ME) and the ID8F3 syngeneic xenograft model using female C57BL/6 mice [37 (link)]. Details of the treatment modalities and assessment are discussed in the Supplementary section . Animal experiments were carried out under the approved protocols and guidelines of the Mayo Clinic Animal Care and Use Committee.
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