Tariquidar-mediated P-gp Inhibition for [11C]Verapamil PET

Tariquidar (MedChemExpress, New
Jersey, USA) was used as a P-gp inhibitor.^{24 (link),29 (link),36 (link)} Tariquidar solution for intravenous
injection was prepared as previously described,^{37 (link)} with 11 mg of Tariquidar methanesulfonate hydrate suspended
in 3 mL of saline solution, and the injection volume was adjusted
to the weight of each monkey (8 mg/kg of body weight). Radiosynthesis
and quality control of (R)-[¹¹C]verapamil
were performed as described previously.^{21 (link)}

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García-Varela L., García D.V., Kakiuchi T., Ohba H., Nishiyama S., Tago T., Elsinga P.H., Tsukada H., Colabufo N.A., Dierckx R.A., van Waarde A., Toyohara J., Boellaard R, & Luurtsema G. (2020). Pharmacokinetic Modeling of (R)-[11C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates. Molecular Pharmaceutics, 18(1), 416-428.

Publication 2020

Tariquidar

Body weight Methanesulfonate Monkey Saline solution Tariquidar

Corresponding Organization : University Medical Center Groningen

Other organizations : Hamamatsu Photonics (Japan), Tokyo Metropolitan Institute of Gerontology, University of Bari Aldo Moro

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Variable analysis

independent variables

Tariquidar (MedChemExpress, New Jersey, USA) as a P-gp inhibitor

dependent variables

Not explicitly mentioned

control variables

Tariquidar solution for intravenous injection was prepared as previously described, with 11 mg of tariquidar methanesulfonate hydrate suspended in 3 mL of saline solution, and the injection volume was adjusted to the weight of each monkey (8 mg/kg of body weight)
Radiosynthesis and quality control of (R)-[11C]verapamil were performed as described previously

controls

Positive control: Not specified
Negative control: Not specified

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