Circadian Rhythm Mice for Vision Research

The present study was carried out in accordance with the European Communities Council Directive of 22 September 2010 (2010/63/EEC) for care of laboratory animals. Male CBA/J (Charles River) and CBA/CaOlaHsd mice (Harlan (Envigo) Laboratories) were group housed in a temperature- and humidity-controled vivarium with a constant 12-h light–dark cycle (lights on from 6 AM to 6 PM) with ad libitum food and water access. The CBA/J (PDE6brd1/PDE6brd1) mouse expresses a hereditary mutation of the PDE6B gene (rd1) (Pittler and Baehr 1991 (link); Cohen et al. 2001 (link)). The CBA/CaOlaHsd mouse (in contrast, for example, to the C57BL/6 mouse) has a circadian cycle-sensitive visual system (Jin and Ribelayga 2016 (link)), with no reported deficits in other sensory modalities (Brooks et al. 2004 (link); Walton et al. 2008 (link); Heckman et al. 2017 (link)) and equivalent cognitive abilities to a variety of lab mouse strains (Brooks et al. 2005 (link)).

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Feldmann M., Beckmann D., Eysel U.T, & Manahan-Vaughan D. (2018). Early Loss of Vision Results in Extensive Reorganization of Plasticity-Related Receptors and Alterations in Hippocampal Function That Extend Through Adulthood. Cerebral Cortex (New York, NY), 29(2), 892-905.

Publication 2018

CBA/J CBA/CaOlaHsd

A gene C57bl mouse Cba mouse Cognitive Food Hereditary mutation Humidity Laboratory animals Lights Male Mouse River Strains

Corresponding Organization : Ruhr University Bochum

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Variable analysis

independent variables

Mouse strain: CBA/J (Charles River) and CBA/CaOlaHsd mice (Harlan (Envigo) Laboratories)

dependent variables

Not explicitly mentioned

control variables

Housing: Group housed in a temperature- and humidity-controlled vivarium
Lighting: Constant 12-h light–dark cycle (lights on from 6 AM to 6 PM)
Access to food and water: Ad libitum

positive controls

None specified

negative controls

None specified

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