The M. tuberculosis strains used in this study were obtained from the culture collection maintained at the Mycobacteriology Laboratory (Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa) and comprised the M. tuberculosis H37Rv ATCC27294T, M. tuberculosis H37RvΔkatG [3 (link)] and seven drug-resistant clinical strains (Table 1 ). Mycobacterium bovis BCG Pasteur ATCC35734 expressing GFP (BCG-GFP) was kindly provided by Prof. M. Niederweis (University of Alabama at Birmingham, USA). Isoniazid, rifampicin, ofloxacin, amikacin, capreomycin, verapamil, flupenthixol, thioridazine, chlorpromazine, haloperidol, and the efflux substrate ethidium bromide were obtained from Sigma-Aldrich (St. Louis, MO, USA).
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