Longitudinal Study of Symptomatic SVD

RUN DMC is a prospective study of symptomatic SVD. Full methodologic details have been published.^{7 (link)} A total of 503 individuals without dementia with radiologic SVD defined as the presence of 1 or more lacunes or WMH were recruited in 2006. Study participants were assessed at baseline and at follow-up in 2011 and in 2015. Assessment included cognitive, MRI, and clinical assessments. We used the baseline MRI data from the 2006 visit and follow-up data on cognition and incidence of dementia from the 2011 and 2015 visits. Follow-up data on dementia incidence were available for 501 participants. MRI sequences, performed on a 1.5T Magnetom scanner (Siemens, Erlangen, Germany), included whole-brain T1-weighted, FLAIR, and gradient echo.