Powder Characterization by LC-MS/MS

After the generated powder sample was fully homogenized using ultrasonic treatment for 5 min, it was dispersed in deionized water. A 0.22 μm organic filter membrane was used for filtration, and an AB SCIEX API4000 type LC-MS/MS System was used for detection. The conditions of the experiment were as follows: The mobile phase was a solution of 0.1 % formic acid. The gradient elution method was used to inject 1 μL of methanol. The column temperature was 35 °C, and the flow rate was adjusted to 0.4 mL/min.

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Zhang X., Huang Y., Huang S., Xie W., Huang W., Chen Y., Li Q., Zeng F, & Liu X. (2024). Antisolvent precipitation for the synergistic preparation of ultrafine particles of nobiletin under ultrasonication-homogenization and evaluation of the inhibitory effects of α-glucosidase and porcine pancreatic lipase in vitro. Ultrasonics Sonochemistry, 105, 106865.

Publication 2024

AB SCIEX API4000

Corresponding Organization : Jiaying University

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Variable analysis

independent variables

Ultrasonic treatment duration (5 min)

dependent variables

Powder sample detection using AB SCIEX API4000 type LC-MS/MS System

control variables

Deionized water for sample dispersion
0.22 μm organic filter membrane for filtration
0.1% formic acid as mobile phase
Gradient elution method with 1 μL methanol injection
Column temperature at 35 °C
Flow rate at 0.4 mL/min

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