Baseline imaging was performed on a 3 Tesla Intera (Philips Healthcare, Best, the Netherlands) MRI scanner with a SENSE 8-channel head coil. 3D T1-weighted and a 3D FLAIR sequences were collected. Pseudocontinuous arterial spin labeling (ASL) sequences with a 2D EPI readout were acquired without and with flow crushing gradients: TR/TE = 4000/17 ms, labeling duration = 1650 ms, post-labeling delay first/last slice = 1525/2080 ms, FOV = 240 × 240 mm, resolution = 3.75 × 3.75 × 7 mm, 17 slices with 7 mm thickness, velocity cut-off of flow-crushing gradients in 3 directions 50 mm/s.15 (link),16 (link) Due to hardware replacement, follow-up imaging used a 3 Tesla Philips Ingenia scanner with a SENSE-16-channel head coil, using the same protocol. pCASL sequence parameters were maintained throughout the study to ensure continuity in the ongoing study. To evaluate comparability between scan results, a purposive sample of nine participants with a broad range of WMH severity were scanned on both scanners before and after hardware replacement, with a median interval of 6.0 months (IQR = 5.6–6.9). Scanning parameters were identical. WMH volumes obtained using automatic segmentation showed excellent agreement between scanners (two-way mixed intraclass correlation coefficient 0.99, p < 0.001).11 (link)