Potential confounders of the relation between schizophrenia and the outcomes were maternal age, parity, neighbourhood income quintile, urban or rural region of residence, and calendar year at the time of the index delivery, as well as maternal substance use disorders and ED visits for interpersonal violence in the 2 years before conception. We considered participants with no postal code to be unstably housed, and therefore assigned them to the lowest income quintile. To describe the cohort, we also recorded nonpsychotic psychiatric diagnoses (including mood disorders and anxiety disorders) and maternal chronic medical conditions (including asthma, congestive heart failure, HIV, hypertension, diabetes, rheumatoid arthritis) present before pregnancy;33 (link),34 (link) however, we did not consider these covariates to be confounders as their development or exacerbation may be a result of ongoing interpersonal violence, and thus may be a proxy for the outcome.35 (link)
Protocol detail
Schizophrenia and Adverse Outcomes
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Anxiety disorders
Asthma
Chronic conditions
Conception
Congestive heart failure
Delivery
Diabetes
Hypertension
Interpersonal violence
Maternal
Mood disorders
Pregnancy
Psychiatric diagnoses
Rheumatoid arthritis
Schizophrenia
Substance use disorders
Corresponding Organization :
Other organizations : St Michael’s Hospital, University of Toronto, Brown University, Hospital for Sick Children, Women's College Hospital
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Variable analysis
independent variables
- Schizophrenia
- Maternal age
- Parity
- Neighbourhood income quintile
- Urban or rural region of residence
- Calendar year at the time of the index delivery
- Maternal substance use disorders
- ED visits for interpersonal violence in the 2 years before conception
- Nonpsychotic psychiatric diagnoses (including mood disorders and anxiety disorders)
- Maternal chronic medical conditions (including asthma, congestive heart failure, HIV, hypertension, diabetes, rheumatoid arthritis)
- Participants with no postal code (considered to be unstably housed, and therefore assigned to the lowest income quintile)
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