Flortaucipir PET Imaging Protocol

Acquisition and processing of [¹⁸F]flortaucipir PET images is described in detail elsewhere [17 (link), 25 , 36 (link)]. In short, dynamic 130-min [¹⁸F]flortaucipir PET scans were acquired on a Philips Ingenuity TF-64 PET/CT scanner. The scanning protocol consisted of two dynamic PET scans of 60 and 50 min, respectively, with an in-between 20-min break [36 (link)]. The first 60-min dynamic scan started simultaneously with a bolus injection of approximately 234 ± 14 MBq [¹⁸F]flortaucipir (injected mass 1.2 ± 0.9 μg). The second PET scan was co-registered to the first dynamic PET scan using Vinci software (Max Planck Institute, Germany). PET data were acquired in list mode and subsequently reconstructed using 3D-RAMLA including standard corrections for dead time, decay, attenuation, random, and scatter. Patients also underwent 3DT1-weighted MRI (Ingenuity TF PET/MR, Philips Medical Systems, The Netherlands) for anatomical and tissue segmentation purposes.

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Visser D., Verfaillie S.C., Wolters E.E., Coomans E.M., Timmers T., Tuncel H., Boellaard R., Golla S.S., Windhorst A.D., Scheltens P., van der Flier W.M., van Berckel B.N, & Ossenkoppele R. (2022). Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer’s disease. European Journal of Nuclear Medicine and Molecular Imaging, 49(6), 1951-1963.

Publication 2022

Ingenuity TF-64 Ingenuity TF PET/MR

Flortaucipir Patients Pet ct Pet scan Scan Tissue

Corresponding Organization : Vrije Universiteit Amsterdam

Other organizations : Lund University

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Variable analysis

independent variables

Injection of approximately 234 ± 14 MBq [18F]flortaucipir (injected mass 1.2 ± 0.9 μg)

dependent variables

Dynamic 130-min [18F]flortaucipir PET scans
Two dynamic PET scans of 60 and 50 min, respectively, with an in-between 20-min break
PET data acquired in list mode and subsequently reconstructed using 3D-RAMLA including standard corrections for dead time, decay, attenuation, random, and scatter

control variables

Philips Ingenuity TF-64 PET/CT scanner
Vinci software (Max Planck Institute, Germany) for co-registration of the second PET scan to the first dynamic PET scan
3DT1-weighted MRI (Ingenuity TF PET/MR, Philips Medical Systems, The Netherlands) for anatomical and tissue segmentation purposes

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