Comparative Myocardial T1 Mapping at 1.5T

Matching pairs of ShMOLLI and MOLLI pre-contrast and post-contrast T1 maps were obtained in 4 female subjects (61 ± 3 years old) without pre-existing cardiac disease who underwent a separate research protocol at 1.5T. Subjects underwent adenosine stress perfusion at 140 μg/kg/min for 3 min, followed by a bolus of Gd (Gadodiamide, Omniscan, GE Healthcare, Amersham, UK, 0.03 mmol/kg body weight). After 20 minutes, resting perfusion imaging was performed using 0.03 mmol/kg of Gd followed immediately by a top-up Gd of 0.10 mmol/kg for LGE imaging. Matching T1-maps were obtained at baseline and ~14 minutes after adenosine stress perfusion. Finally, 4 pairs of images were collected before, and one after, the LGE images. The dynamic evolution of T1 recovery after the final Gd bolus was corrected with 3^rd order polynomial for the purpose of constructing Bland-Altman plots.