Stroke Biomarkers and Outcomes

The variables collected included demographics (age and gender), medical histories (hypertension, atrial fibrillation, diabetes, hyperlipidemia, and coronary heart diseases), the National Institute of Health Stroke Scale (NIHSS) score, the Alberta Stroke Program Early CT Score (ASPECTS), hemorrhagic transformation (30 (link)), reperfusion therapy method, and the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification (31 (link)). Successful recanalization after endovascular therapy was defined as a modified Thrombolysis in Cerebral Infarction grading system score of 2b or 3 (32 (link)). Blood samples were collected for laboratory measurements in the emergency department. White blood cell (WBC) counts, including absolute numbers of neutrophils were measured using an automated hematology analyzer (Sysmex, Kobe, Japan). Serum albumin levels were determined with an Olympus AU-5400 automatic analyzer (Olympus, Tokyo, Japan).

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Cui T., Wang C., Zhu Q., Li S., Yang Y., Wang A., Zhang X., Shang W, & Wu B. (2022). Association between neutrophil percentage-to-albumin ratio and 3-month functional outcome in acute ischemic stroke patients with reperfusion therapy. Frontiers in Neurology, 13, 898226.

Publication 2022

automated hematology analyzer AU-5400 automatic analyzer

Acute stroke Atrial fibrillation Blood Cerebral infarction Coronary heart diseases Diabetes Gender Hemorrhagic Hyperlipidemia Hypertension Neutrophils Org 10172 Reperfusion therapy Serum albumin Stroke Therapy Thrombolysis White blood cell counts

Corresponding Organization : Sichuan University

Other organizations : Shanxi Medical University, Shaanxi Provincial People's Hospital

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Variable analysis

independent variables

Reperfusion therapy method
Successful recanalization after endovascular therapy (defined as a modified Thrombolysis in Cerebral Infarction grading system score of 2b or 3)

dependent variables

Hemorrhagic transformation (30)
TOAST classification (31)

control variables

Demographics (age and gender)
Medical histories (hypertension, atrial fibrillation, diabetes, hyperlipidemia, and coronary heart diseases)
NIHSS score
ASPECTS
White blood cell (WBC) counts, including absolute numbers of neutrophils
Serum albumin levels

unspecified variables

Independent variables not explicitly mentioned.
Dependent variables not explicitly mentioned.
Control variables not explicitly mentioned.

controls

Positive controls: None mentioned.
Negative controls: None mentioned.

Annotations

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