TMA construction was achieved as previously described [29 (link)]. Immunohistochemistry was performed as previously described [30 (link)]. For ADAR2 immunostaining, we used rabbit anti‐ADAR2 (Santa Cruz Biotechnology Cat# sc‐73409, RRID:AB_2289194) antibody. TMA spots with a lack of tumor tissue were excluded from the analysis, resulting in the analysis of 178 patients' samples. Immunohistochemical evaluation of the TMAs was conducted by two independent observers in a blinded manner. The average H‐score of all the cores obtained from the same tumor specimen was determined by the percentage of cells having nuclear ADAR2 positivity and scored as 0 (0%), 1 (1–9%), 2 (10–49%), or 3 (50% and more). BAP1 staining was performed as previously described [29 (link)] and BAP1 immunohistochemistry data was stratified into four groups: nuclear only, cytoplasmic only, absent, and combination of nuclear and cytoplasmic as recently described [23 (link)].
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