Antimicrobial Susceptibility of Mtb Strains

MICs against Mtb H37Rv isogenic strains mono-resistant to rifampin (ATCC-35838), isoniazid (ATCC-35822), kanamycin (ATCC-35827), Cycloserin (ATCC-35826). The rMOX and rCAP strains were obtained by the Institute for Tuberculosis Research, University of Illinois at Chicago. MIC values against 6 clinical strains from different lineages and with different drug susceptibility profiles: KMA3899 Lineage 1, Indo-Oceanic (East African-Indian [EAI]); KMA4244 Lineage 2, East Asian (Beijing); KMA4439 Lineage 2, East Asian (Beijing); KMA1354 Lineage 3, East African-Asian (Central Asian [CAS]); KMA5282 Lineage 4, Euro-American (Haarlem, Latin-American Mediterranean [LAM], T, X); KMA5319 Lineage 4, Euro-American (Haarlem, LAM, T, X).

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Zhang J., Lair C., Roubert C., Amaning K., Barrio M.B., Benedetti Y., Cui Z., Xing Z., Li X., Franzblau S.G., Baurin N., Bordon-Pallier F., Cantalloube C., Sans S., Silve S., Blanc I., Fraisse L., Rak A., Jenner L.B., Yusupova G., Yusupov M., Zhang J., Kaneko T., Yang T.J., Fotouhi N., Nuermberger E., Tyagi S., Betoudji F., Upton A., Sacchettini J.C, & Lagrange S. (2023). Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Cell, 186(5), 1013-1025.e24.

Publication 2023

African Asian Central asian Drug East african East asian Isoniazid Kanamycin Rifampin Strains Susceptibility Tuberculosis

Corresponding Organization :

Other organizations : Sanofi (France), Evotec (United States), Texas A&M University, University of Illinois at Chicago, Institut de génétique et de biologie moléculaire et cellulaire, TB Alliance, Johns Hopkins Medicine, Johns Hopkins University

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Variable analysis

independent variables

Isogenic strains of Mycobacterium tuberculosis H37Rv resistant to rifampin (ATCC-35838), isoniazid (ATCC-35822), kanamycin (ATCC-35827), and cycloserin (ATCC-35826)
RMOX and rCAP strains obtained from the Institute for Tuberculosis Research, University of Illinois at Chicago
6 clinical strains of Mycobacterium tuberculosis from different lineages and with different drug susceptibility profiles: KMA3899 (Lineage 1, Indo-Oceanic [EAI]), KMA4244 (Lineage 2, East Asian [Beijing]), KMA4439 (Lineage 2, East Asian [Beijing]), KMA1354 (Lineage 3, East African-Asian [CAS]), KMA5282 (Lineage 4, Euro-American [Haarlem, LAM, T, X]), KMA5319 (Lineage 4, Euro-American [Haarlem, LAM, T, X])

dependent variables

Minimum Inhibitory Concentrations (MICs) against the Mycobacterium tuberculosis strains

control variables

Mycobacterium tuberculosis H37Rv strain

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