Formulation and Characterization of Propofol Nanoemulsions

Propofol (purity 99.9%) was obtained from Incepta Pharmaceuticals Ltd. (Dhaka, Bangladesh). Zanthoxylum rhetsa seed oil (ZRO) was collected by a steam distillation process from naturally obtained seeds (no organic solvent was used). Medium-chain triglycerides (carbon chain length 8–12), Miglyol 810 (M810), and corn oil (CO) were purchased from Sasol Germany GmbH (Werk, Witten, Germany). Capmul MCM (C10) mono/diglycerides of capric acid were purchased from Abitec Corp. Janesville, USA. Maisine 35–1 (long-chain monoglycerides) was obtained from Gattefosse SAS, (Saint-Priest, France). Kolliphor ELP and Kolliphor HS15 were purchased from BASF, Ludwigshafen, Germany. Tween 80 (polyoxyethylene sorbitan monooleate) was obtained from Sigma Aldrich, USA. HPLC-grade acetonitrile, methanol, formic acid, and phosphoric acid were obtained from BDH Chemicals Ltd., Poole, UK. Milli-Q water was obtained through a Milli-Q Integral Water Purification System (Millipore, Bedford, MA). All other reagents were of analytical grade and used without further purification.

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Kazi M., Alqahtani A., Alharbi M., Ahmad A., Hussain M.D., Alothaid H, & Aldughaim M.S. (2023). The Development and Optimization of Lipid-Based Self-Nanoemulsifying Drug Delivery Systems for the Intravenous Delivery of Propofol. Molecules, 28(3), 1492.

Publication 2023

Maisine 35–1 Kolliphor ELP Kolliphor HS15 Tween 80 (polyoxyethylene sorbitan monooleate) HPLC-grade acetonitrile methanol formic acid phosphoric acid Water Purification System

Acetonitrile Capmul mcm Capric acid Carbon 12 Corn oil Diglycerides Distillation Formic acid Hplc Methanol Miglyol 810 Monoglycerides Pharmaceuticals Phosphoric acid Polyoxyethylene Propofol Seeds Solvent Sorbitan monooleate Steam Triglycerides Tween 80 Zanthoxylum

Corresponding Organization : King Fahd Medical City

Other organizations : King Saud University, Husson University, Al Baha University

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Variable analysis

independent variables

Propofol (purity 99.9%)
Zanthoxylum rhetsa seed oil (ZRO)
Medium-chain triglycerides (carbon chain length 8–12)
Miglyol 810 (M810)
Corn oil (CO)
Capmul MCM (C10) mono/diglycerides of capric acid
Maisine 35–1 (long-chain monoglycerides)
Kolliphor ELP
Kolliphor HS15
Tween 80 (polyoxyethylene sorbitan monooleate)

dependent variables

Not explicitly mentioned

control variables

HPLC-grade acetonitrile, methanol, formic acid, and phosphoric acid
Milli-Q water

positive controls

Not explicitly mentioned

negative controls

Not explicitly mentioned

Annotations

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