Premature and Full-Term Newborn Study

Premature and full-term (FT) newborns recorded between January 2021 and January 2022 were included in this prospective study. Premature newborns were consecutively included for 8 months. Out of 210 premature newborns, 11 did not meet the inclusion criteria (congenital malformations, chromosomic anomalies, and digestive pathologies other than NEC), there were 13 cases of non-consent, and 29 samples were unavailable (insufficient amounts, technical problems). Full-term (FT) newborns were included consecutively for one month. Among the 280 newborns, 9 did not meet the inclusion criteria (congenital malformations, chromosomic anomalies, and digestive pathologies), there were 36 cases of non-consent, and 78 samples were unavailable. Newborns were considered premature if born before 37 gestational weeks (GW) and were classified into three groups: less than 28 GW (Group A), between 28 GW and 31 GW and 6 days (Group B), and between 32 GW and 36 GW and 6 days (Group C). Gestational weeks were calculated as amenorrhea weeks. Premature newborns under 22 GW and weighing less than 500 g were excluded. Full-term newborns (Group D) were recruited in two stages: a first cohort for tryptase assays and a second for calprotectin (tryptase and calprotectin populations). Newborns were considered hypotrophic when their BW was below the 10th percentile.

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Paysal J., Oris C., Troin U., Limeri P.N., Allard J., Tadrent M., Pereira B., Merlin E., Rochette E., Evrard B., Durif J., Sapin V, & Pons M. (2023). Influence of Perinatal Factors on Blood Tryptase and Fecal Calprotectin Levels in Newborns. Children, 10(2), 345.

Publication 2023

Assays Born Calprotectin Chromosomic anomalies Congenital malformations Digestive Gestational Newborns Populations Premature Tryptase

Corresponding Organization :

Other organizations : Centre Hospitalier Universitaire de Clermont-Ferrand

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Variable analysis

independent variables

Prematurity
Gestational age

dependent variables

Tryptase levels
Calprotectin levels

control variables

Congenital malformations
Chromosomic anomalies
Digestive pathologies
Gestational age (< 22 weeks and < 500 g)
Birth weight (below 10th percentile)

positive controls

Full-term (FT) newborns

negative controls

Newborns who did not meet the inclusion criteria (congenital malformations, chromosomic anomalies, and digestive pathologies)

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