Example 9
3-(Difluoromethyl)-4-iodo-1-methyl-1H-pyrazole (50 g) was added to a mixture of potassium carbonate (52.6 g), copper iodide (3.56 g) and sulfur powder (18.25 g) in dimethylformamide (DMF, 400 g). The reaction mixture was heated to a temperature of 110° C. and stirred for 3 to 4 hours at the same temperature. The progress of the reaction was monitored by Gas chromatography (GC). The reaction mixture was concentrated at a temperature of about 80° C. using reduced pressure of about 50 mbar to obtain a residue. Dichloromethane (150 ml) was added to the residue and filtered through hyflo super cell. The filter cake was washed with dichloromethane (150 ml). Organic layer was washed with water (500 ml×2). The organic layer was concentrated to obtain the desired product. GCMS 326+
Example 10
3-(Difluoromethyl)-4-iodo-1-methyl-1H-pyrazole (50 g) was added to a mixture of potassium carbonate (52.6 g), copper iodide (3.56 g) and sulfur powder (18.25 g) in sulfolane (400 g). The reaction mixture was proceeded as per example 9. GCMS 326+
