Mannose-alkyne
was fabricated as
previously described.23 (link) All diblock copolymers
were fabricated using 4-cyano-4-(ethylsulfanylthiocarbonyl)-sulfanylpentanoic
acid (ECT) as a chain-transfer agent (CTA) conjugated to either azide-PEG
(AzPEG) or PEG. ECT was synthesized as previously described.62 (link),63 (link) The AzPEG and PEG macro-CTAs were then RAFT-polymerized with DMAEMA
and BMA at a 50:50 molar ratio as previously described.23 (link)−25 (link) AzPEGDB was then conjugated with mannose-alkyne via CuAAC chemistry
to produce MnPEGDB. All polymers were characterized using 1H nuclear magnetic resonance (1H NMR) spectroscopy (Bruker,
400 MHz), Fourier transform infrared spectroscopy (FTIR, Bruker Tensor
27), and a copper assay kit (Sigma-Aldrich). All NMR spectra are shown
in Supporting InformationFigures S2–S4 . Details for the polymer synthesis appear in Supporting Information Materials and Methods .
was fabricated as
previously described.23 (link) All diblock copolymers
were fabricated using 4-cyano-4-(ethylsulfanylthiocarbonyl)-sulfanylpentanoic
acid (ECT) as a chain-transfer agent (CTA) conjugated to either azide-PEG
(AzPEG) or PEG. ECT was synthesized as previously described.62 (link),63 (link) The AzPEG and PEG macro-CTAs were then RAFT-polymerized with DMAEMA
and BMA at a 50:50 molar ratio as previously described.23 (link)−25 (link) AzPEGDB was then conjugated with mannose-alkyne via CuAAC chemistry
to produce MnPEGDB. All polymers were characterized using 1H nuclear magnetic resonance (1H NMR) spectroscopy (Bruker,
400 MHz), Fourier transform infrared spectroscopy (FTIR, Bruker Tensor
27), and a copper assay kit (Sigma-Aldrich). All NMR spectra are shown
in Supporting Information
