Antibiotic-induced Gut Microbiome Modulation

At the beginning of the 5th week of CD or HSD supplementation, the mice were provided with drinking water containing an antibiotic cocktail (ampicillin, 1 g/L; neomycin sulfate, 1 g/L; metronidazole, 1 g/L; and vancomycin, 500 mg/L; Sangon Biotech (Shanghai) Co., Ltd.) for 4 weeks ad libitum in the meantime (27 (link)). The antibiotics were renewed every other day. After 4 weeks of antibiotic treatment, the mice were treated with zymosan A, and the peritoneal fluid was collected for further experiments.

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Li W., Wu P., Jin T., Jia J., Chen B., Liu T., Liu Y., Mei J., Luo B, & Zhang Z. (2024). L-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation. Frontiers in Immunology, 15, 1333848.

Publication 2024

ampicillin neomycin sulfate metronidazole vancomycin

Corresponding Organization :

Other organizations : Army Medical University, Xinqiao Hospital, Chongqing Medical University, Guizhou University

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Variable analysis

independent variables

Antibiotic cocktail (ampicillin, 1 g/L; neomycin sulfate, 1 g/L; metronidazole, 1 g/L; and vancomycin, 500 mg/L)

dependent variables

Peritoneal fluid

control variables

Drinking water
Time period (4 weeks)

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

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