Synthesis of 2-Aryl-quinoline-4-carboxylic Acid Methyl Ester
2-Aryl-quinoline-4-carboxylic acid (3, 10 mmol) was suspended in SOCl2 (12 mmol) at 0 °C. The mixture was refluxed for 2 h and cooled to 0 °C. Methanol (5 mL) was added to get the hydrochloride salt of the methyl ester derivative. Cold water (15 mL) was added to the mixture and its pH was adjusted to 7.0 with saturated with aqueous NaHCO3 solution. The precipitated solid was filtered, washed with cold water (2 × 10 mL), and dried under reduced pressure to get 2-(phenyl derivates)-quinoline-4-carboxylic acid methyl ester.
Hamedifar H., Mirfattahi M., Khalili Ghomi M., Azizian H., Iraji A., Noori M., Moazzam A., Dastyafteh N., Nokhbehzaim A., Mehrpour K., Javanshir S., Mojtabavi S., Faramarzi M.A., Larijani B., Hajimiri M.H, & Mahdavi M. (2024). Aryl-quinoline-4-carbonyl hydrazone bearing different 2-methoxyphenoxyacetamides as potent α-glucosidase inhibitors; molecular dynamics, kinetic and structure–activity relationship studies. Scientific Reports, 14, 388.
Publication 2024
Corresponding Organization :
Other organizations :
Biotechnology Research Center, Tehran University of Medical Sciences, Iran University of Medical Sciences, Shiraz University of Medical Sciences, Iran University of Science and Technology, Jahrom University of Medical Sciences
No positive or negative controls were explicitly mentioned.
Annotations
Based on most similar protocols
Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.
As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to
get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
