Diagnosis of Ischemic Heart Disease and Stroke

The outcome of the study was the first recorded diagnosis of IHD (including angina pectoris) or stroke event, defined by the presence of diagnosis, hospitalization, and treatment or rehabilitation records. The ICD-10 codes for each outcome are presented in Supplementary Table 1. IHD was considered an event when record of the focal diagnosis (Supplementary Table 1), hospitalization, and treatment occurred in the same month. IHD treatment included percutaneous coronary intervention and coronary artery bypass operations (Supplementary Table 2). Stroke was considered as an event when record of the focal diagnosis (Supplementary Table 1), hospitalization, and treatment occurred in the same month, and any kind of rehabilitation occurred within two months from the diagnosis. Stroke treatment included computed tomography or magnetic resonance imaging followed by medication (antithrombotic agents, ATC code: B01 or edaravone, ATC code: N07X0) or surgical procedures expected to be performed as a part of stroke treatment. In both of the study outcome events, death caused by the focal disease before hospitalization was excluded from the events.