Experimental setup for contrast-enhanced magnetic resonance angiography. A, Over 3 days, 6 healthy New Zealand female rabbits received 4 doses of gadopiclenol (0.025, 0.05, 0.075, and 0.1 mmol Gd/kg) and 1 dose of gadoterate meglumine (0.1 mmol Gd/kg). A minimum interval of 5 hours was fixed between 2 injections to allow for elimination of the CA/dose from the previous injection. At each dose, MRI was performed before injection and for 6 time points after injection (synchronized with the beginning of the injection, at 25, 50, 180, 300, and 600 seconds). B, Six healthy female farm pigs received 2 doses of CAs 1 week apart: a half gadolinium dose for gadopiclenol (0.05 mmol Gd/kg) and a full gadolinium dose for gadoterate meglumine (0.1 mmol Gd/kg). At each dose, MRI was performed before injection and a Care Bolus sequence was used to determine the arrival of CA in the aorta to initiate the 3D MRA sequence.