Chemovirotherapy for Liver Cancer

Each patient in this study received three cycles of uniform treatment protocols. The Seldinger technique was performed as previously reported.30 (link) Carboplatin at a dose of 300 mg (Bristol-Myers Squibb, NY, New York, USA) was used for hepatic artery infusion chemotherapy. Subsequently, 50 mg epirubicin (Pharmorubicin, Pfizer, Wuxi, Jiangsu, China) and 6 mg mitomycin (Zhejiang Hisun Pharmaceutical Co. Ltd., Taizhou, Zhejiang, China) mixed with Lipiodol (Lipiodol Ultra-Fluide; Andre Guerbet Laboratories, France) were used for chemolipiodolization. The Lipiodol dose was determined based on tumor location, size, and number and ranged from 5 to 30 mL. Sterile-purified H101 viruses were produced for human clinical use by Shanghai Sunway Biotech (Shanghai, China) and safety tested by the National Institute for the Control of Pharmaceutical and Biological Products (Beijing, China). Before the infusion chemotherapy, H101 was injected via catheter into the hepatic artery supplying the tumor(s). A total of 1.0 × 10¹² virus particles in 10 mL of 0.9% sodium chloride solution were administered.31 (link)