The XYS formula was composed of eight herbal medicines. The composition and dose of the prescription is listed in Table 1. The raw herbs were obtained from the Tongrentang (Bozhou, Anhui, China) Decoction Pieces Limited Company, and then authenticated by Dr. B. Liu (department of Botany of Beijing, University of Chinese Medicine). The drugs were extracted by the Chinese medicine preparation room of China-Japan Friendship Hospital as previously described [19 ]. The extraction rate was 18.8%, and the quality control of XYS was identified by high-performance liquid chromatography-mass spectrometry analysis (LC-MS/MS).

Composition of XYS

Medicinal plantAmount (g)
Poria((Poria cocos (Schw.) Wolf))15
Rhizoma Zingiberis Recens (Zingiber officinale Rosc.)15
Radix Angelicae Sinensis (Angelica sinensis (Oliv.) Diels)15
Rhizoma Atractylodis Macrocephalae (Atractylodes macrocephala Koidz.)15
Radix Paeoniae Alba (Paeonia lactiflora Pall.)15
Radix Glycyrrhizae (Glycyrrhiza uralensis Fisch.),6
Herba Menthae (Mentha haplocalyx Briq.)6
Radix Bupleuri (Bupleurum chinense DC.)15
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