Quantifying Thigh Muscle Composition via 3D Dixon MRI
All patients were examined in a Philips Achieva XR 1.5 Teslas located at HSCSP. We used the same positioning protocol for all patients: supine position with legs stretched, the patella facing upward and the ankles in a neutral position. 3D 3-point Dixon images were acquired with the following acquisition parameters: TR/TE = 5.78/1.8, 4 ms, flip angle = 15°, FOV = 520 × 340 × 300 mm, voxel size = 1 × 1 × 3 mm. Analysis of the 3-point Dixon MR images was performed using the PRIDE (Philips Research Image Development Environment) tool, as has been reported previously15 (link),42 (link). ROIs were manually drawn on five slices of the following muscles: rectus femoris, vastus intermedius, vastus lateralis, vastus medialis, adductor magnus, sartorius, gracilis, semitendinosus and semimembranosus, and on three slices of biceps femoris long head, biceps femoris short head and adductor longus
Fernández-Simón E., Carrasco-Rozas A., Gallardo E., Figueroa-Bonaparte S., Belmonte I., Pedrosa I., Montiel E., Suárez-Calvet X., Alonso-Pérez J., Segovia S., Nuñez-Peralta C., Llauger J., Mayos M., Illa I, & Díaz-Manera J. (2019). PDGF-BB serum levels are decreased in adult onset Pompe patients. Scientific Reports, 9, 2139.
Other organizations :
Universitat Autònoma de Barcelona, Hospital de Sant Pau, Instituto de Investigación de Enfermedades Raras, Centre for Biomedical Network Research on Rare Diseases, Hospital General Universitario de Albacete, Hospital de Cruces, Hospital Universitario Puerta de Hierro Majadahonda, Hospital Universitario Virgen de las Nieves, Hospital Universitari Germans Trias i Pujol, Hospital Universitario De Cabueñes, Research Institute Hospital 12 de Octubre, Donostia Unibertsitate Ospitalea, Complexo Hospitalario Universitario A Coruña, Hospital Clínic de Barcelona, University of Córdoba, Hospital Universitario Nuestra Señora de Candelaria, Hospital Universitario Virgen de la Arrixaca, Hospital Universitario de Valme, Hospital General Universitario Morales Meseguer, Central University Hospital of Asturias, Hospital General Universitario Gregorio Marañón, Hospital Sant Joan de Déu Barcelona, Hospital Universitario Virgen del Rocío, Hospital Can Misses, Hospital Juan Ramón Jiménez, Hospital Universitario Virgen Macarena, Hospital Regional Universitario de Málaga, Hospital Son Llatzer
No positive or negative controls were explicitly mentioned.
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