Taiwanese Han-Chinese Biobank Cohort

TWB is an extensive community-based database that facilitates large-scale cohort studies and case-control studies on various diseases by combining genetic and clinical information from healthy volunteers and patients from Taiwan (18 (link)). It has recruited participants between 30 and 70 years of age with no history of cancer. The hospital-based component has recruited patients affected by the most common chronic diseases in Taiwan, including CVD, diabetes, chronic kidney disease, and so on. This study includes a total of 15,996 Taiwanese subjects of Han-Chinese ancestry (randomly selected from 2008 to 2015) from TWB that were genotyped using the Axiom-Taiwan Biobank Array Plate (TWB chip; Affymetrix Inc, CA, USA). The genotype data consist of a total of 653,291 gene variant sites and 646,735 SNPs. The TWB study was approved by the ethics committee at Taichung Veterans General Hospital (IRB: TCVGHNo.CE16270B-2). Consent was not obtained because the data were de-identified.

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Chiu P.C., Chattopadhyay A., Wu M.C., Hsiao T.H., Lin C.H, & Lu T.P. (2021). Elucidation of a Causal Relationship Between Platelet Count and Hypertension: A Bi-Directional Mendelian Randomization Study. Frontiers in Cardiovascular Medicine, 8, 743075.

Publication 2021

Axiom-Taiwan Biobank Array Plate (TWB chip;

Cancer Chinese Chip Chronic diseases Chronic kidney disease Diabetes Ethics committee Gene Genetic Genotype Healthy volunteers Patients Snps

Corresponding Organization : National Taiwan University

Other organizations : Taichung Veterans General Hospital

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Various diseases including CVD, diabetes, chronic kidney disease

control variables

Participants were healthy volunteers and patients from Taiwan between 30 and 70 years of age with no history of cancer

controls

The study included both healthy volunteers and patients affected by chronic diseases in Taiwan, which can be considered as positive and negative controls, respectively.

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