sEVs of the HEK293T cell were isolated according to the protocol that was reported previously (Lim et al., 2020 (link), 2021 (link)). After 4 days of culturing, cell‐conditioned medium was collected and subjected to differential centrifugation to remove cells, debris, and large EVs. Then, the supernatant was filtered through a 0.22‐μm Millex‐GV filter (Merck Millipore, MA, USA) to generate a final pre‐cleared cell conditioned medium, known as the 10K sup. After that, a MagCapture Exosome Isolation Kit PS (Wako, Osaka, Japan) was used following to the manufacturer's manual to purify the sEVs from the 10K sup. The purified sEVs were kept in a dialysis membrane (3500 MWCO) for overnight dialysis in PBS. NanoSIGHT LM10 (Malvern Panalytical, Malvern, UK) was used to perform nanoparticle tracking analysis (NTA) to measure the sEV concentration. The sEV purification process follows the Minimal Information for Studies of Extracellular Vesicle 2018 (MISEV2018) guidelines (Théry et al., 2018 (link)) because we uploaded the protocol to the EV‐TRACK knowledgebase in our earlier study (Lim et al., 2021 (link)) (EV‐TRACK ID: EV210256).