We also searched the National Human Genome Research Institute (NHGRI) GWAS Catalog for previous SNP-trait associations near our lead SNPs73 (link). We supplemented the catalog with additional genome-wide significant SNP-trait associations from the literature13 (link),70 (link),74 (link)-80 (link). We used PLINK to identify SNPs within 500 kb of lead SNPs using 1000 Genomes Project Pilot I genotype data and LD (r2) values from CEU81 (link),82 (link); for rs7759742, HapMap release 22 CEU data81 (link),83 (link) were used. All SNPs within the specified regions were compared with the NHGRI GWAS Catalog16 .
Cardiovascular Trait Association Analysis
We also searched the National Human Genome Research Institute (NHGRI) GWAS Catalog for previous SNP-trait associations near our lead SNPs73 (link). We supplemented the catalog with additional genome-wide significant SNP-trait associations from the literature13 (link),70 (link),74 (link)-80 (link). We used PLINK to identify SNPs within 500 kb of lead SNPs using 1000 Genomes Project Pilot I genotype data and LD (r2) values from CEU81 (link),82 (link); for rs7759742, HapMap release 22 CEU data81 (link),83 (link) were used. All SNPs within the specified regions were compared with the NHGRI GWAS Catalog16 .
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Other organizations : Umeå University, University of Regensburg, Brigham and Women's Hospital, Harvard University, Wellcome Centre for Human Genetics, University of Oxford, University of Michigan–Ann Arbor, Karolinska Institutet, Boston Children's Hospital, University of Tartu, University of North Carolina at Chapel Hill, Boston University, Framingham Heart Study, National Heart Lung and Blood Institute, Science for Life Laboratory, Uppsala University, MRC Epidemiology Unit, University of Cambridge, University Hospital of Lausanne, Institute of Social and Preventive Medicine, Institut für Medizinische Informatik, Biometrie und Epidemiologie, University of Exeter, University Medical Center Groningen, University of Groningen, HudsonAlpha Institute for Biotechnology, Erasmus MC, The Kids Research Institute Australia, University of Western Australia, Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Rutgers, The State University of New Jersey, Johns Hopkins Medicine, Johns Hopkins University, Washington University in St. Louis, SIB Swiss Institute of Bioinformatics, University Medical Centre Mannheim, Heidelberg University, University Hospital Heidelberg, Finnish Institute for Health and Welfare, King's College London, University of Eastern Finland, National Institute on Aging, Universitätsmedizin Greifswald, Université de Lille, Centre National de la Recherche Scientifique, Ealing Hospital, Ealing Hospital NHS Trust, Helmholtz Zentrum München, Pathwest Laboratory Medicine, Azienda Sanitaria di Firenze, Oxford Centre for Diabetes, Endocrinology and Metabolism, Texas Biomedical Research Institute, IFB Adiposity Diseases, Université de Rennes, Inserm, University of San Carlos, Norwegian University of Science and Technology, University of Southern California, Ninewells Hospital, University of Dundee, National Human Genome Research Institute, Broad Institute, Massachusetts Institute of Technology, Kaiser Permanente, University Hospital of Geneva, University Hospital Carl Gustav Carus, TU Dresden, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, University of Helsinki, University of Oulu, University of Utah, Harokopio University of Athens, Universität Ulm, Innsbruck Medical University, University of Gothenburg, University of Bristol, Life & Brain (Germany), University of Bonn, Institute of Genetic and Biomedical Research, National Institutes of Health, University of Sassari, Wellcome Sanger Institute, Skåne University Hospital, Lund University, Medical University of Graz, University of Washington, Icelandic Heart Association, Loyola University Chicago, University of Chicago, Heinrich Heine University Düsseldorf, Deutsches Diabetes-Zentrum e.V., German Center for Diabetes Research, deCODE Genetics (Iceland), Erasmus University Rotterdam, UiT The Arctic University of Norway, MRC Unit for Lifelong Health and Ageing, University College London, University College Dublin, Seoul National University, Columbia University, Harvard Pilgrim Health Care, Shanghai Institute of Hematology, Shanghai Jiao Tong University, William Harvey Research Institute, Queen Mary University of London, Howard Hughes Medical Institute, Yale University, Queen's University Belfast, University of Ottawa, Imperial College London, QIMR Berghofer Medical Research Institute, Aalto University, Icahn School of Medicine at Mount Sinai, Tecnológico de Monterrey, Institut Pasteur de Lille, Université de Strasbourg, Cedars-Sinai Medical Center, Addenbrooke's Hospital, Vanderbilt University Medical Center, Center for Human Genetics, Vrije Universiteit Amsterdam, West German Heart and Vascular Center Essen, Deutsches Herzzentrum München, University of Pisa, Hôpital Rangueil, University of the West Indies, Eurac Research, University of Lübeck, University of South Australia, Institute for Molecular Medicine Finland, Fred Hutch Cancer Center, Kuopio University Hospital, Cancer Center of Hawaii, University of Hawaiʻi at Mānoa, University of Hawaii System, Fimlab (Finland), Tampere University, Steno Diabetes Center, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Sir Charles Gairdner Hospital, University of Toronto, Turku University Hospital, Pennington Biomedical Research Center, Pennsylvania State University, Glenfield Hospital, University of Leicester, South Karelia Central Hospital, University of Maryland, Baltimore, Maastricht University, Leipzig University, Centro Cardiologico Monzino, University of Lausanne, Nanyang Technological University, Wake Forest University, Centre for Medical Systems Biology, Stanford University, Finnish Diabetes Association, Helsinki University Hospital, University of Insubria, Newcastle University, Ludwig-Maximilians-Universität München, National Cancer Institute, Albert Einstein College of Medicine, St George's, University of London, University of Queensland, University of Liverpool
Protocol cited in 95 other protocols
Variable analysis
- Lead SNPs
- Association with 22 cardio-metabolic traits
- Previous SNP-trait associations near lead SNPs
- Proxies (r^2>0.80 in CEU) when an index SNP was unavailable
- SNPs within 500 kb of lead SNPs using 1000 Genomes Project Pilot I genotype data and LD (r^2) values from CEU
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