The present studies sought to (1) identify hubs within the human cerebral cortex, (2) determine the stability of hubs across subject groups and task states, and (3) explore whether the locations of hubs correlated with one component of AD pathology (Aβ deposition). The basic analytic strategy was to compute an estimate of the functional connectivity of each voxel within the brain. Regions showing a high degree of connectivity across participants were considered candidate hubs. Our primary measure of connectivity -- degree centrality or degree -- was defined as the number of voxels across the brain that showed strong correlation with the target voxel. Using this procedure, a map of candidate hubs was computed for an average of 24 participants (Data Set 1) and replicated in a second group of 24 participants (Data Set 2). Data Sets 1 and 2 were acquired while participants fixated on a cross-hair. As the results will reveal, the locations of cortical hubs were highly similar between participant groups. To explore in more detail the connectivity patterns of the identified hubs, we employed seed-based and formal network analyses on the combined data set (n=48). To explore whether the identified hubs reflect a stable property of cortex or were task dependent, maps of hubs were estimated in a third group of 12 participants (Data Set 3) that varied the task performed during data collection (passive visual fixation versus continuous task performance). Similar hubs were present across task states. To provide a consensus estimate of the locations of cortical hubs, the data across 127 participants were combined. The consensus estimate was compared to a map of Aβ deposition in early-stage AD obtained using PiB positron emission tomography (PET) imaging to explore whether hub regions are preferentially associated with the locations of Aβ accumulation. To aid visualization, all image maps were projected on to the left and right cerebral hemispheres of the inflated PALS surface using Caret software (Van Essen, 2005 (link)).