Following genotyping using a custom content Affymetrix Axiom SNP array, imputation of classical HLA alleles per locus (i.e. class I: HLA-A, HLA-B, HLA-C and class II: HLA-DP, HLA-DQ, HLA-DR) at four-digit resolution was performed with HIBAG[25 (link)]. The genotyping and HLA imputation have been described previously[15 (link)]. As part of the exploratory nature of these analyses, we aimed to explore associations with HLA alleles carried by ≥10 participants including those observed at low frequencies.
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Genotyping and HLA Imputation Protocol
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Corresponding Organization : Rigshospitalet
Other organizations : UNSW Sydney, University of Minnesota, Medical Research Council, University College London, Washington University Medical Center, George Washington University, National Institute of Allergy and Infectious Diseases
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Variable analysis
independent variables
- HLA alleles carried by ≥10 participants including those observed at low frequencies
- Not explicitly mentioned
- Genotyping using a custom content Affymetrix Axiom SNP array
- Imputation of classical HLA alleles per locus (i.e. class I: HLA-A, HLA-B, HLA-C and class II: HLA-DP, HLA-DQ, HLA-DR) at four-digit resolution was performed with HIBAG
- No positive or negative controls were explicitly mentioned
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