The Korean National Cancer Screening Program (KNCSP) is a national program operated by the South Korean government and is designed to screen for cancers in the stomach, liver, colorectum, breast, and cervix according to specific recommendations (15 (link)). The results of the KNCSP are stored in the National Health Insurance Sharing Service-National Health Information Database (NHIS-NHID); the use of this data is approved for authorised researchers. In South Korea, the NHIS provides medical services covered by the national health insurance for >50 million individuals (approximately 97% of the entire population) (16 (link)).
In the KNCSP for screening colorectal cancer (CRC), the government provides an annual faecal immunochemical test (FIT) for individuals aged ≥50 years to screen for CRC. In addition, for those with positive FIT results, the NHIS provides subsequent examinations by either double-contrast barium enema or colonoscopy, based on the preference of the individual. In this study, data of the population who participated in the KNCSP for CRC between 2009–2013, including data from the NHIS, were utilised. and participants were followed up until December 21, 2019. Details of the study design, participants, and data acquisition have been described previously (17 (link)). This study was approved by the institutional review board of Ajou University Hospital (approval No. AJIRB-MED-EXP-20-479). The requirement for obtaining individual informed consent was waived because the entire dataset was anonymised.
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