High-throughput single nucleotide polymorphism genotyping was carried out in all available family members (n = 6) (Fig. 1a) using the HumanOmniExpress Exome arrays v1.3 and HiScanSQ system (Illumina Inc., San Diego, CA, USA). The GenomeStudio program (GS; Illumina) was used to undertake quality assessments and generate PLINK input reports9 (link) for HM, and HM analyses were carried out as previously described.10 (link), 11 (link)
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