Based on previous reports, we used an experimental model with surgical destabilization of the medial meniscus (DMM), which exhibits severe cartilage degradation and cartilage damage characteristic of OA.24 (link) The medial meniscus tibial ligament of C57BL/6 mice was made unstable during DMM surgery. In the sham group, no joint tissue was manipulated during surgery. We divided the mice into five groups at random: Sham group; DMM group; E.G. low group (E.G. L group); E.G. medium group (E.G. M group) and E.G. high group (E.G. H group). According to animal dose conversion table, we then determined the dose of the experimental group. After OA modeling, mice in E.G. high group received E.G. treatment at a dose of 1.17 g/kg/day orally for 12 consecutive weeks. Ratio of high, medium and low-dose groups is 4:2:1. Physiological saline was administered orally to mice in both the sham and DMM groups.