Engineered Mouse Models for Myeloid Malignancies

Sf3b1^K700E, Srsf2^P95H, HSC-Scl-Cre^ERT, Rosa26-Lox-STOP-Lox-Cas9-EGFP, Tet2 floxed, and Mx1-cre mice were obtained from The Jackson Laboratory and were previously generated and described^{13 (link),19 (link),26 (link)} with the exception of HSC-Scl-Cre^ERT mice^{44 (link)} (which were obtained from Dr. Joachim R Göthert).

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Inoue D., Polaski J.T., Taylor J., Castel P., Chen S., Kobayashi S., Hogg S.J., Hayashi Y., Pineda J.M., El Marabti E., Erickson C., Knorr K., Fukumoto M., Yamazaki H., Tanaka A., Fukui C., Lu S.X., Durham B.H., Liu B., Wang E., Mehta S., Zakheim D., Garippa R., Penson A., Chew G.L., McCormick F., Bradley R.K, & Abdel-Wahab O. (2021). Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nature genetics, 53(5), 707-718.

Publication 2021

Sf3b1K700E Srsf2P95H HSC-Scl-CreERT Rosa26-Lox-STOP-Lox-Cas9-EGFP Tet2 floxed Mx1-cre HSC-Scl-CreERT mice

Mice

Corresponding Organization :

Other organizations : Foundation for Biomedical Research and Innovation, Fred Hutch Cancer Center, Sylvester Comprehensive Cancer Center, University of Miami, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, Memorial Sloan Kettering Cancer Center, National University of Singapore, National University Cancer Institute, Singapore, University of Washington

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Variable analysis

independent variables

Sf3b1^K700E
Srsf2^P95H
HSC-Scl-Cre^ERT
Rosa26-Lox-STOP-Lox-Cas9-EGFP
Tet2 floxed
Mx1-cre

dependent variables

Not explicitly mentioned

control variables

Not explicitly mentioned

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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