Anti-malarial Compounds Characterization

DSM267 and DSM265 were gifts from M. Phillips from University of Texas (UT) Southwestern (35 (link)). l-dihydroorotic acid (DHO) was purchased from Sigma-Aldrich (St. Louis, MO). Amodiaquine, artemether, atovaquone, chloroquine, dihydroartemisinin, and mefloquine were purchased from Sigma-Aldrich (St. Louis, MO).

Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link: Access Free Full Text.

Mandt R.E., Lafuente-Monasterio M.J., Sakata-Kato T., Luth M.R., Segura D., Pablos-Tanarro A., Viera S., Magan N., Ottilie S., Winzeler E.A., Lukens A.K., Gamo F.J, & Wirth D.F. (2019). In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Science translational medicine, 11(521), eaav1636.

Publication 2019

Amodiaquine artemether atovaquone chloroquine dihydroartemisinin mefloquine

Acid Amodiaquine Artemether Atovaquone Chloroquine Dihydroartemisinin Dsm265 Gifts Mefloquine

Corresponding Organization : Broad Institute

Other organizations : University of California, San Diego, University of Montana

Top 5 similar protocols

Variable analysis

independent variables

DSM267
DSM265

dependent variables

Not explicitly mentioned

control variables

Amodiaquine
Artemether
Atovaquone
Chloroquine
Dihydroartemisinin
Mefloquine
L-dihydroorotic acid (DHO)

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!