Combination Drug Synergy Analysis

ARS-1620 and BI-3406 was purchased from MedChemExpress. AMG-510, Erlotinib, Afatinib, AZD-4547, Linsitinib, Imatinib, Cabozantinib, Ceritinib, GDC-0941 and RXDX-106 were purchased from Selleckchem. Drugs were reconstituted in DMSO to 10 mM stock concentrations and stored at −80^oC. The combination index (CI) was calculated using CompuSyn software (20 (link)). The coefficient of drug interaction (CDI) was calculated using the following formula; CDI = AB/(A × B) (21 (link)).

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Solanki H.S., Welsh E.A., Fang B., Izumi V., Darville L., Stone B., Franzese R., Chavan S., Kinose F., Imbody D., Koomen J.M., Rix U, & Haura E.B. (2021). Cell-type Specific Adaptive Signaling Responses to KRASG12C inhibition. Clinical cancer research : an official journal of the American Association for Cancer Research, 27(9), 2533-2548.

Publication 2021

ARS-1620 BI-3406 AMG-510 Erlotinib Afatinib AZD-4547 Linsitinib Imatinib Cabozantinib Ceritinib GDC-0941 RXDX-106

Afatinib Amg 510 Ars 1620 Cabozantinib Ceritinib Dmso Drug interaction Drugs Erlotinib Gdc 0941 Imatinib Linsitinib Rxdx 106

Corresponding Organization :

Other organizations : Moffitt Cancer Center, Molecular Oncology (United States), University of South Florida

Top 5 similar protocols

Variable analysis

independent variables

ARS-1620
BI-3406
AMG-510
Erlotinib
Afatinib
AZD-4547
Linsitinib
Imatinib
Cabozantinib
Ceritinib
GDC-0941
RXDX-106

dependent variables

Combination index (CI)
Coefficient of drug interaction (CDI)

control variables

Drugs were reconstituted in DMSO to 10 mM stock concentrations and stored at −80°C

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