Multi-modal Neuroimaging Data Processing

Voxel-wise T2 maps were reconstructed with monoexponential nonnegative least-squares fitting of the multi-echo signals (MapIt; Siemens Medical Solutions). T2 maps were registered to T1-weighted images with the parameters of the registration between the first echo T2-weighted image and T1-weighted image. Meanwhile, voxels with T2 values larger than 170 ms were excluded to alleviate cerebrospinal fluid (CSF) contaminations [31 (link)].
The FDG standard uptake value ratios (SUVRs) from PET images were obtained by intensity normalization via global mean scaling to correct individual variations [32 (link)]. The SUVR maps were also registered to T1-weighted images. All image registrations were employed with rigid registration (6 degrees-of-freedom) using SPM12 (https://www.fil.ion.ucl.ac.uk/spm/).

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Zhang M., Huang H., Liu W., Tang L., Li Q., Wang J., Huang X., Lin X., Meng H., Wang J., Zhan S., Li B, & Luo J. (2022). Combined quantitative T2 mapping and [18F]FDG PET could improve lateralization of mesial temporal lobe epilepsy. European Radiology, 32(9), 6108-6117.

Publication 2022

MapIt

Cerebrospinal fluid Echo Maps Rigid

Corresponding Organization : Ruijin Hospital

Other organizations : Shanghai Jiao Tong University

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Variable analysis

independent variables

T2 values larger than 170 ms were excluded to alleviate cerebrospinal fluid (CSF) contaminations

dependent variables

Voxel-wise T2 maps
FDG standard uptake value ratios (SUVRs) from PET images

control variables

T2 maps were registered to T1-weighted images
SUVR maps were also registered to T1-weighted images
All image registrations were employed with rigid registration (6 degrees-of-freedom) using SPM12

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