The injection solution of haloperidol (5 mg/ml ampoules, 5 mg/ml ampoules, Sabex Inc. Boucherville, Quebec, Canada) was obtained by mixing drugs with sterile water. The injection solution of phencyclidine hydrochloride (gift from National Institute on Drug Abuse Chemical Synthesis and Drug Supply Program) was obtained by mixing drugs with 0.9% saline. Clozapine (gift from the NIMH drug supply program) and olanzapine (Toronto Research Chemical Inc., Canada) were dissolved in 1.5% glacial acetic acid distilled water. The doses of haloperidol (0.03 or 0.05 mg/kg), olanzapine (1.0 or 2.0 mg/kg), Clozapine (5 and 10 mg/kg) and PCP (1.60 or 3.20 mg/kg) were chosen based on our previous work (Sun et al., 2009 (link); Sun et al., 2010 (link); Zhang and Li, 2012 (link); Zhao et al., 2012b (link); Feng et al., 2013 (link)). All drugs were administered s.c. at 1.0 ml/kg.
Protocol detail
Antipsychotic Drug Preparation and Dosing
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0 9 saline
Clozapine
Drugs
Glacial acetic acid
Haloperidol
Olanzapine
Phencyclidine hydrochloride
Sterile
Corresponding Organization :
Other organizations : University of Nebraska–Lincoln, Nanjing University, Nanjing General Hospital of Nanjing Military Command
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Variable analysis
independent variables
- Dose of haloperidol (0.03 or 0.05 mg/kg)
- Dose of olanzapine (1.0 or 2.0 mg/kg)
- Dose of clozapine (5 and 10 mg/kg)
- Dose of phencyclidine (PCP) (1.60 or 3.20 mg/kg)
- Not explicitly mentioned
- Injection solution of haloperidol (5 mg/ml ampoules, Sabex Inc. Boucherville, Quebec, Canada)
- Injection solution of phencyclidine hydrochloride (gift from National Institute on Drug Abuse Chemical Synthesis and Drug Supply Program)
- Clozapine (gift from the NIMH drug supply program)
- Olanzapine (Toronto Research Chemical Inc., Canada)
- All drugs were administered s.c. at 1.0 ml/kg
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