Frontal White Matter Integrity Assessment

Imaging was performed at the Research Imaging Institute, University of Texas Health Science Center at San Antonio. All imaging data were collected using a Siemens Tim Trio 3T MR system (Erlangen, Germany) equipped with a 12 channel head coil. This study combined functional magnetic resonance imaging (fMRI) collected during go/no-go task performance with two measurements of frontal white matter integrity derived from diffusion tensor imaging (DTI) and proton magnetic resonance spectroscopy (1H-MRS) (Wijtenburg et al. 2012 (link)). The two measures of white matter integrity used, fractional anisotropy of water diffusion and concentrations of the N-acetylaspartate from the anterior corona radiata, were included because they were shown to be reduced in FH+ subjects (Acheson et al. 2014b (link),c (link)).

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Acheson A., Tagamets M.A., Winkler A., Rowland L.M., Mathias C.W., Wright S.N., Hong L.E., Kochunov P, & Dougherty D.M. (2015). Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance-use disorders performing a go/no-go task. Brain and Behavior, 5(7), e00352.

Publication 2015

Tim Trio 3T MR system

1h mrs Anisotropy Diffusion Head Task performance Trio White matter

Corresponding Organization : The University of Texas Health Science Center at San Antonio

Other organizations : University of Maryland, Baltimore, University of Oxford, Yale University, Wellcome Centre for Integrative Neuroimaging, Johns Hopkins University

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Variable analysis

independent variables

Frontal white matter integrity derived from diffusion tensor imaging (DTI)
Frontal white matter integrity derived from proton magnetic resonance spectroscopy (1H-MRS)

dependent variables

Functional magnetic resonance imaging (fMRI) collected during go/no-go task performance

control variables

Imaging data collected using a Siemens Tim Trio 3T MR system (Erlangen, Germany) equipped with a 12 channel head coil

controls

Positive control: Fractional anisotropy of water diffusion and concentrations of the N-acetylaspartate from the anterior corona radiata, as they were shown to be reduced in FH+ subjects (Acheson et al. 2014b, c).
Negative control: Not explicitly mentioned.

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