We assumed that the risk-adjusted odds ratio (OR) relating comorbidity (measured as Charlson Comorbidity Index) to in-hospital mortality in patients diagnosed with AMI was 1.17 (95 % CI, 1.11–1.23) as reported in a seven-year longitudinal study that assessed the impact of comorbidities on in-hospital mortality among a similar population of male and female patients diagnosed with AMI [30 (link)]. The risk-adjusted OR was derived from a multivariable regression model that accounted for age, sex, Charlson Comorbidity Index, and coronary revascularisation. Comorbidity prevalence in adult hospitalised patients with and without an AMI was set as 35 % [based on a multi-centre ten-year study] [31 (link)] and 32 % [based on data from six countries] [32 (link)].
All analyses were performed using Stata statistical program (version 13, StataCorp, College Station, TX, USA). Statistical significance was set at a P value of < 0.05 (two-sided).
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