Hippocampal Synaptosome Isolation

Synaptosomes were isolated from the hippocampi of 3- and 16-mo-old mice as recently described (33 (link)).

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Castro-Hernández R., Berulava T., Metelova M., Epple R., Peña Centeno T., Richter J., Kaurani L., Pradhan R., Sakib M.S., Burkhardt S., Ninov M., Bohnsack K.E., Bohnsack M.T., Delalle I, & Fischer A. (2023). Conserved reduction of m6A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts. Proceedings of the National Academy of Sciences of the United States of America, 120(9), e2204933120.

Publication 2023

Hippocampi 3 Mice Synaptosomes

Corresponding Organization :

Other organizations : German Center for Neurodegenerative Diseases, Max Planck Institute for Biophysical Chemistry, University of Göttingen, Lifespan, Providence College, Brown University

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Variable analysis

independent variables

Age of mice (3-month-old vs. 16-month-old)

dependent variables

Characteristics of synaptosomes isolated from the hippocampi of the mice

control variables

Hippocampi of the mice

controls

No positive or negative controls were explicitly mentioned in the provided information.

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