Thirty mice were randomized into four groups: TBI + ω-3 and TBI + ω-3 + GW9662 groups (n = 15/group). TBI + ω-3 and TBI + ω-3 + GW9662 groups received same dosage ω-3 PUFA. Mice in the TBI + ω-3 group received intraperitoneal injection of normal saline, TBI + ω-3 + GW9662 group received intraperitoneal injection of GW9662 (1 mg/kg, M2748, AbMole) once daily for 5 consecutive days, beginning about 2 days before the TBI.
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