Comparative PET/CT Imaging with 18F-FDG and 18F-FCH

Both [¹⁸F]FDG PET/CT and [¹⁸F]FCH PET/CT were performed using the standard protocol for each technique [15 (link),16 (link)]. Preparation prior to image acquisition included fasting for at least 4 h and proper hydration.
[¹⁸F]FCH was injected following a quadratic relation between [¹⁸F]FCH dose and the patient’s body mass. Whole-body PET/CT acquisition was performed 60 min after injection. Choline tracers have physiological uptake by the liver, spleen, pancreas, salivary and lachrymal glands, and urinary tract (due to renal excretion). Less uptake tracer could be seen in bone marrow and intestine [17 (link)].
[¹⁸F]FDG was injected following a quadratic relation between [¹⁸F]FDG dose and the patient’s body mass [18 (link)]. Whole-body PET/CT acquisition was performed 60 min after injection. [¹⁸F]FDG has physiological uptake by the brain, myocardium, kidneys, urinary tract, liver, and spleen.
Imaging was performed in an integrated PET/CT scanner (Siemens Biograph 6 Hi-Rez). Attenuation correction was performed with a low-dose spiral CT-based method (120 kV, 80 mA) and PET emission data were acquired in 2-dimensional mode. PET data were reconstructed using a method of ordered-subsets (8 subsets, 4 iterations, and Gaussian filtering).

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Garrastachu Zumarán P., García Megías I., Mangas Losada M., Mendoza Melero A., Villanueva Torres A., Boulvard Chollet X., Romero Robles L., Hernández Pérez P.M., Ramírez Lasanta R, & Delgado Bolton R.C. (2023). Multitracer PET/CT with [18F]Fluorodeoxiglucose and [18F]Fluorocholine in the Initial Staging of Multiple Myeloma Patients Applying the IMPeTus Criteria: A Pilot Study. Diagnostics, 13(9), 1570.

Publication 2023

Biograph 6 Hi-Rez

18f fdg Body Bone marrow Brain Choline Intestine Kidneys Lachrymal glands Liver Myocardium Pancreas Patient Pet ct Physiological Renal excretion Seen Spiral ct Spleen Urinary tract

Corresponding Organization : Center for Biomedical Research of La Rioja

Top 5 similar protocols

Variable analysis

independent variables

[18F]FDG dose
[18F]FCH dose

dependent variables

Whole-body PET/CT acquisition

control variables

Fasting for at least 4 hours
Proper hydration
Quadratic relation between tracer dose and patient's body mass
Whole-body PET/CT acquisition performed 60 min after injection
Attenuation correction performed with low-dose spiral CT-based method
PET emission data acquired in 2-dimensional mode
PET data reconstructed using ordered-subsets method

controls

Positive control: Physiological uptake of [18F]FDG by the brain, myocardium, kidneys, urinary tract, liver, and spleen
Positive control: Physiological uptake of [18F]FCH by the liver, spleen, pancreas, salivary and lachrymal glands, and urinary tract

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