SARS-CoV-2 Testing Strategies in Alberta

As part of its public health strategy, Alberta offered SARS-CoV-2 molecular testing beginning in January 2020 for travel-related requests using a gel-based reverse transcriptase PCR (RT-PCR) assay (COVID-19-specific and pan-coronavirus) (4 (link)). From February 2020 onward, laboratory-developed real-time RT-PCR assays targeting the SARS-CoV-2 envelope (E) and/or RNA-dependent-RNA-polymerase (RdRp) were implemented, followed by a laboratory-developed E/RdRp/MS2 multiplex assay or Seegene (2019-nCoV assay, Seegene), Xpert (Xpress SARS-CoV-2, Cepheid), Aptima (SARS-CoV-2 assay, Hologic), BD Max (BioGX SARS-CoV-2, BD Molecular Diagnostics), Simplexa (COVID-19 direct test, DiaSorin), or cobas 6800 (SARS-CoV-2 test, Roche) testing (depending on laboratory testing location) for all symptomatic patients (27 (link), 28 (link)). Between 29 May 2020 and 4 November 2020, broad asymptomatic testing was made available to all Albertans.

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Charlton C.L., Nguyen L.T., Bailey A., Fenton J., Plitt S.S., Marohn C., Lau C., Hinshaw D., Lutsiak C., Simmonds K., Kanji J.N., Zelyas N., Lee N., Mengel M, & Tipples G. (2021). Pre-Vaccine Positivity of SARS-CoV-2 Antibodies in Alberta, Canada during the First Two Waves of the COVID-19 Pandemic. Microbiology Spectrum, 9(1), 10.1128/spectrum.00291-21.

Publication 2021

Xpress SARS-CoV-2, Aptima ( SARS-CoV-2 assay, COVID-19 direct test cobas 6800 SARS-CoV-2 test,

Assay Coronavirus Covid 19 Molecular diagnostics Patients Real time pcr Reverse transcriptase Reverse transcriptase pcr Rna dependent rna polymerase Sars cov 2

Corresponding Organization : University of Calgary

Other organizations : Alberta Hospital Edmonton, Public Health Agency of Canada

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Variable analysis

independent variables

Molecular testing methods for SARS-CoV-2 detection
Implementation of different laboratory-developed RT-PCR assays
Availability of broad asymptomatic testing

dependent variables

Public health strategy for SARS-CoV-2 detection

control variables

Not explicitly mentioned

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

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