Histomorphometric Analysis of Bone Augmentation

Digital images were semi-automatically segmented, and tissue types were classified: (1) pre-existing/native bone of the SF, (2) newly formed bone, (3) bone substitute material, and (4) soft tissue/marrow area within the augmented area (AA). Particles smaller than 0.008 mm² were considered to be debris and ascribed to void space. Inaccurately classified areas were manually corrected under microscopic control (Adobe Photoshop, Adobe, San Jose, CA, USA). Segmentation and histomorphometric measurements were performed using Definiens Developer XD 2.7 (Definiens, Munich, Germany).
The following histomorphometric parameters were assessed in serial 100 µm zones starting from the native bone of the SF towards the apical end of the biopsies [20 (link)].

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Reich K.M., Beck F., Heimel P., Lettner S., Redl H., Ulm C, & Tangl S. (2022). Bone Graft Packing and Its Association with Bone Regeneration in Maxillary Sinus Floor Augmentations: Histomorphometric Analysis of Human Biopsies. Biology, 11(10), 1431.

Publication 2022

Definiens Developer XD 2.7

Biopsies Bone Bone substitute Formed bone Marrow Microscopic Tissue Tissue types Void

Corresponding Organization : Austrian Cluster for Tissue Regeneration

Other organizations : Ludwig Boltzmann Institute for Experimental and Clinical Traumatology

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Variable analysis

independent variables

Serial 100 µm zones starting from the native bone of the SF towards the apical end of the biopsies

dependent variables

Histomorphometric parameters assessed in the serial 100 µm zones

control variables

Particles smaller than 0.008 mm² were considered to be debris and ascribed to void space
Inaccurately classified areas were manually corrected under microscopic control (Adobe Photoshop, Adobe, San Jose, CA, USA)

controls

Positive control: Not specified
Negative control: Not specified

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