Genetic Comparison of African Americans with Type 2 Diabetes

The AA-DHS contained AAs with T2DM recruited from two Wake Forest School of Medicine (WFSM) studies: the Diabetes Heart Study (DHS) and African American-DHS. DHS is a cross-sectional study of EA and AA families with siblings concordant for T2DM. AA-DHS started after DHS and enrolled only unrelated AAs. AA-DHS objectives were to improve understanding of the striking ethnic differences in CAC observed between AAs and EAs. T2DM was diagnosed after the age of 30 years in the absence of diabetic ketoacidosis. The DHS “family of studies” is described in Bowden et al.^{13 (link)}. Subjects who underwent prior coronary artery bypass surgery were not included in the MALD analysis, as the CAC mass score could be impacted^{14 (link)}. Those with prior myocardial infarction or stroke were included. The final analysis included 635 unrelated AAs obtained by selecting all AA-DHS participants and one AA from each of 150 DHS sibpairs (the sibling with the most complete phenotypic data and best kidney function). The study was approved by the WFSM Institutional Review Board; all participants provided written informed consent.

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Divers J., Palmer N.D., Lu L., Register T.C., Carr J.J., Hicks P.J., Hightower R.C., Smith S.C., Xu J., Cox A.J., Hruska K.A., Bowden D.W., Lewis C.E., Heiss G., Province M.A., Borecki I.B., Kerr K.F., Chen Y.D., Palmas W., Rotter J.I., Wassel C.L., Bertoni A., Herrington D., Wagenknecht L.E., Langefeld C.D, & Freedman B.I. (2012). Admixture Mapping of Coronary Artery Calcified Plaque in African Americans with Type 2 Diabetes. Circulation. Cardiovascular genetics, 6(1), 97-105.

Publication 2012

African american Coronary artery bypass surgery Diabetes Diabetic ketoacidosis Forest Heart Institutional review board Kidney Medicine Myocardial infarction Phenotypic Stroke

Corresponding Organization :

Other organizations : University of Washington, University of Alabama at Birmingham, University of North Carolina at Chapel Hill, Cedars-Sinai Medical Center, Columbia University, University of California, San Diego

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Protocol cited in 9 other protocols

Variable analysis

independent variables

Ethnicity (AA vs. EA)

dependent variables

Coronary artery calcium (CAC) mass score

control variables

Diagnosis of type 2 diabetes mellitus (T2DM) after age 30 years in the absence of diabetic ketoacidosis
Exclusion of subjects with prior coronary artery bypass surgery

controls

Positive controls not explicitly mentioned
Negative controls not explicitly mentioned

Annotations

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