Study participants were at least 18 years of age, had type 1 or 2 diabetes, had at least one eye with a best corrected visual-acuity letter score (range, 0 to 100, with higher scores indicating better visual acuity) of 78 (approximate Snellen equivalent, 20/32) to 24 (approximate Snellen equivalent, 20/320) and center-involved diabetic macular edema on clinical examination and optical coherence tomography (OCT) according to protocol-defined thresholds, and had received no anti-VEGF treatment within the previous 12 months. Other eligibility criteria are listed in Table S1 in the Supplementary Appendix , available at NEJM.org.
Protocol detail
Diabetic Macular Edema Treatment Protocol
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Clinical examination
Diabetes
Eligibility
Macular edema
Optical coherence tomography
Vegf
Visual acuity
Corresponding Organization :
Other organizations : Palmetto Retina Center, Jaeb Center for Health Research, Northwestern University, Harvard University Press, ENT and Allergy Associates of Florida, Pain Management Center of Paducah, Johns Hopkins University, Elman Retina Group, National Institutes of Health, California Retina Consultants
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Variable analysis
independent variables
- Anti-VEGF treatment
- Best corrected visual-acuity letter score (range, 0 to 100, with higher scores indicating better visual acuity)
- Participants were at least 18 years of age
- Participants had type 1 or 2 diabetes
- Participants had at least one eye with a best corrected visual-acuity letter score of 78 (approximate Snellen equivalent, 20/32) to 24 (approximate Snellen equivalent, 20/320)
- Participants had center-involved diabetic macular edema on clinical examination and optical coherence tomography (OCT) according to protocol-defined thresholds
- Participants had received no anti-VEGF treatment within the previous 12 months
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