High-Resolution Structural Brain Imaging

High-resolution structural imaging was acquired on a Siemens 3.0 T Magnetom Trio Tim MR scanner (the first dataset) or General Electric (GE) Discovery MR750 3.0 T scanner (the second dataset) using protocols described elsewhere (Xi et al., 2016 (link); Cui et al., 2017a (link),b (link)). All the imaging data were collected in the Department of Radiology, Xijing Hospital. A custom-built head coil cushion and earplugs were used to minimize head motion and dampen scanner noise. During data acquisition, subjects were asked to remain alert with eyes closed and keep their head still. Participants in dataset 1 underwent scanning using a 3.0-T Siemens Magnetom Trio Tim scanner and an eight-channel phased array head coil (Siemens, Germany). Participants in dataset 2 underwent scans on a GE Discovery MR750 3.0-T scanner and an eight-channel phased array head coil (Milwaukee, WI, United States). Detailed parameters of high-resolution T1-weighted anatomical data are listed in Table 2. As performed previously (Cui et al., 2018 (link)), steps for the following analysis are shown in Figure 1.