MR images were acquired on a 3 Tesla Siemens MAGNETOM Verio scanner (Syngo MR B17, Siemens, Munich, Germany) using a 32-channel head coil. High-resolution T1-weighted MPRAGE sequences were acquired using a 3D magnetization-prepared rapid gradient echo imaging protocol (224 sagittal slices, voxel size: 1 mm × 1 mm × 1 mm, TR: 2500 ms, TE: 3.47 ms, TI: 1100 ms, and flip angle: 7°).
Voxel-based morphometry (VBM) is a whole-brain unbiased technique for the analysis of regional GM volume and tissue changes [35 (link)]. Preprocessing involved gray-matter segmentation, template creation via DARTEL, spatial normalization to standardized Montreal Neurological Institute (MNI) space, and smoothing with a Gaussian kernel of 8 mm full width at half maximum (FWHM). Whole-brain analysis was performed first and was followed by region of interest (ROI)-analysis of the medial temporal lobe regions, including the hippocampus and the parahippocampus on both sides.
Voxel-based morphometry (VBM) is a whole-brain unbiased technique for the analysis of regional GM volume and tissue changes [35 (link)]. Preprocessing involved gray-matter segmentation, template creation via DARTEL, spatial normalization to standardized Montreal Neurological Institute (MNI) space, and smoothing with a Gaussian kernel of 8 mm full width at half maximum (FWHM). Whole-brain analysis was performed first and was followed by region of interest (ROI)-analysis of the medial temporal lobe regions, including the hippocampus and the parahippocampus on both sides.
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