Amyloid PET Imaging Protocols for Lewy Body Dementia

Imaging was performed at baseline. Details of the MRI and PET acquisition and analysis have been published previously.^{23 (link)
25} In summary, PET-Aβ imaging data were available for 59 participants with LBD. For the NIMROD and MILOS cohort 550 MBq of [11^C] PIB PET imaging was carried out using a GE Advance PET scanner (GE Healthcare) or a GE Discovery 690 PET/CT, with attenuation correction provided by a transmission scan or a low dose CT scan, with 550 MBq of PIB injected as a bolus and imaging performed for 30 min starting at 40 min post injection. Participants were considered PET-Aβ-positive using a cutpoint of 19 on the centiloid scale.^{28 (link)}For the AMPLE cohort imaging was performed using a Siemens Biograph-40 PET-CT scanner. Participants were given a 370 MBq intravenous injection of ¹⁸F-florbetapir (Amyvid). PET imaging was carried out for 15 min, commencing 30−50 min after injection. Attenuation correction was performed using CT scan data. Amyloid PET images were visually rated as positive or negative based on the manufacturer’s criteria by a panel of five raters.^{23 (link)}